Download PDF Using the right therapeutics can help keep the symptoms of a virus suppressed and the potential need for hospitalization as well (as a lot of misery). Recently I posted an information request on Facebook for therapeutics people felt worked good in their experience for COVID-19, thanks to everyone for submitting your experiences and remedies of choice. There are many others (besides the list below) that came in but I did my best to condense. My quick list for my COVID-19 tool-chest would be: vitamin C, vitamin D, Zinc, Melatonin, Elderberry and Aspirin (Asthma inhaler steroid, Zyrtec and Mucinex in case conditions get worse).Vitamin C: helps with proper functioning of the immune system.Vitamin D: Vitamin D can modulate the innate and adaptive immune responses. Deficiency in vitamin D is associated with increased autoimmunity as well as an increased susceptibility to infection. Zinc: is critical for the development and function of immune cells and has been shown to shorten length of colds. It seems to do this by possibly keeping the virus from replicating itself. The National Institutes of Health (NIH) considers 40 mg of zinc a day to be the upper limit dose for adults and 4 mg of zinc a day for infants under age 6 months.Don't use intranasal zinc: this form of zinc has been linked with the loss of the sense of smell.Melatonin: enhances both innate and cellular immunity. Abstract from NIH: Melatonin has the potential therapeutic value to enhance immune function in aged individuals and in patients in an immunocompromised state. Elderberry: Elderberry from (Sambucus nigra) is used mostly as a supplement to treat cold and flu symptoms. Its history as medicine dates back to 400 BC. Hippocrates, the “Father of Medicine,” called the elder tree his “medicine chest.” In natural/traditional medicine, the elderberry is considered one of the world’s most healing plants. Green Tea: appears to have the potential to block the various phases of infection of healthy cells, thus weakening a virus and reducing the duration of cold-like symptoms and fever.Aspirin: COVID-19 can cause an inflammatory condition of the lungs, and coagulation of the blood, (aspirin is both an anti-inflammatory and anticoagulant). I would take aspirin multiple times a day with food. There were quite a few that used Tylenol as well and seemed to like it.Mucinex: was one of the most referred to in usage for over the counter medicine and seems to give really good results according to the feedback I got. It seems to help by simply thinning and loosening mucus in your airways and clearing congestion and in doing so, makes breathing easier.Pepsid (famotidine): seems to really show potential in helping control histamine production thus appears to bridal the cytokine storm that causes difficulty breathing. Zyrtec (Cetirizine): is an antihistamine used to relieve allergy symptoms such as watery eyes, runny nose, itching eyes/nose, sneezing, hives, and itching. It works by blocking a certain natural substance (histamine) that your body makes during an allergic reaction. Alegra D Symbicort inhaler (Budesonide): are called preventers. They work by calming down your immune system. This reduces the swelling in your lungs that makes it difficult to breathe. If Budesonide is unavailable, other steroid inhalers seem to work as well.Hydroxychloroquine (Plaquenil): seems to still be a favorite for controlling the immune response. I would not use in combination with the Z-Pack.Ivermectin: Ivermectin is a drug of a wide range of bioactivity and has been in use for more than 30 years for treatment of parasitic infections in humans. It is being considered as the possible target drug for SARS CoV-2 and is under extensive research in clinical trials. I used to sell this in our family store in the form of cattle wormer and heart worm tablets for dogs.Colchicine: Anti-inflammatory- Colchicine is used to prevent gout attacks and seems to have a controlling affect on the immune response in the lungs as well, (since it is used when gout attacks occur, it should have a fairly rapid affect). Note: I would not recommend using Pepsid (famotidine), Hydroxychloroquine or Zyrtec in combination (but rather pick one) as they seem to both work toward controlling the inflammatory response (cytokine storm). The cytokine storm sounds bad (and seems to be the primary culprit in sending people to the hospital due to difficulty breathing). However this is actually your immune system trying to kill the invader, so you don’t want to completely turn-off the response. You just don’t want the immune response reaction to kill you with an over-intense battle with the invader.Hydration: Drink Pedialyte, Gatorade Zero, Powerade Zero, water with electrolytes, water with lemon (and a little honey), peppermint tea, apple cider and green tea are good fluids to stay hydrated with and taste good warm/hot. As much as you can, stay away from eating or drinking anything cold (your body has to heat it up to body temperature and doing this takes energy). I like drinking warm/hot fluids and soups to help assist the sweating process. Diet: easy to digest, warm foods (such as soups) to keep your body from spending a lot of energy on digestion but rather spend it on squashing the virus and pushing it out of your system. Other things to add in: when you have pressure on lungs, stay vertical as much as possible and lay on stomach or side when resting/sleeping. Use a humidifier to counter dry heat in the house, probiotics, pulse oximeter- (for checking oxygen), Spirometer (or balloons) for exercising lungs. I hope this helps give you and your family therapeutics needed to suppress the symptoms until your immune system maps the virus (for antibody production). The CDC says if you're having trouble breathing, have chest pains, are confused or have bluish lips, that is when you should seek emergency care. Download PDF _______________________________________________________________________________________________________Other research below and citations for the above article: (please come back as this will continue to evolve).
Vitamin C: also known as ascorbic acid, is necessary for the growth, development and repair of all body tissues. It's involved in many body functions, including formation of collagen, absorption of iron, the proper functioning of the immune system, wound healing, and the maintenance of cartilage, bones, and teeth. And could shorten the length of colds. https://ods.od.nih.gov/factsheets/VitaminC-Consumer/
Vitamin D: Vitamin D can modulate the innate and adaptive immune responses. Deficiency in vitamin D is associated with increased autoimmunity as well as an increased susceptibility to infection.Excerpt NIH: It is now clear that vitamin D has important roles in addition to its classic effects on calcium and bone homeostasis. As the vitamin D receptor is expressed on immune cells (B cells, T cells and antigen presenting cells) and these immunologic cells are all are capable of synthesizing the active vitamin D metabolite, vitamin D has the capability of acting in an autocrine manner in a local immunologic milieu. Vitamin D can modulate the innate and adaptive immune responses. Deficiency in vitamin D is associated with increased autoimmunity as well as an increased susceptibility to infection. As immune cells in autoimmune diseases are responsive to the ameliorative effects of vitamin D, the beneficial effects of supplementing vitamin D deficient individuals with autoimmune disease may extend beyond the effects on bone and calcium homeostasis.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166406/
Zinc: Zinc is necessary for the activity of over 300 enzymes that aid in metabolism, digestion, nerve function and many other processes ( 3 ). In addition, it's critical for the development and function of immune cells ( 4 ). This mineral is also fundamental to skin health, DNA synthesis and protein production.When oral zinc is taken long term and in high doses it can cause copper deficiency. People with low copper levels might experience neurological issues, such as numbness and weakness in the arms and legs.
The National Institutes of Health considers 40 mg of zinc a day to be the upper limit dose for adults and 4 mg of zinc a day for infants under age 6 months.
Don't use intranasal zinc: this form of zinc has been linked with the loss of the sense of smell.https://www.mayoclinic.org/drugs-supplements-zinc/art-20366112
Melatonin: enhances both innate and cellular immunity. It stimulates the production of progenitor cells of granulocytes and macrophages and of NK cells. Production of IL-2, IL-6 and IL-12 is stimulated by melatonin. Increased T-helper production, particularly of CD4+ cells, occurs after melatonin supplementation.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1325257/
Elderberry: Although there’s no one-size-fits-all remedy for illness, supporters of elderberry say the fruit is one of nature’s most versatile solutions for what ails you.There are about 30 types of elder plants and trees around the world. The European version (also known as Sambucus nigra) is the one most closely tied to your health and healing. Its history dates back as far as 400 BC, and Hippocrates, the “Father of Medicine,” called the elder tree his “medicine chest.” In folk medicine today, the elderberry is considered one of the world’s most healing plants.https://www.webmd.com/diet/elderberry-health-benefits#1 Intercontinental air travel can be stressful, especially for respiratory health. Elderberries have been used traditionally, and in some observational and clinical studies, as supportive agents against the common cold and influenza. This randomized, double-blind placebo-controlled clinical trial of 312 economy class passengers traveling from Australia to an overseas destination aimed to investigate if a standardized membrane filtered elderberry (Sambucus nigra L.) extract has beneficial effects on physical, especially respiratory, and mental health. Cold episodes, cold duration and symptoms were noted in a daily diary and assessed using the Jackson score. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848651/
Green Tea: ”The antioxidants in green tea have been found to block the various phases of infection of healthy cells, weakening a virus and reducing the duration of cold-like symptoms and fever." This may be because green tea's antioxidant polyphenols could affect regulatory T-cells that play a key role in immune function.https://www.businessinsider.com/what-people-who-never-get-sick-do-everyday-2017-12#they-go-for-green-tea-17 One of the beneficial compounds found in green tea has a powerful ability to increase the number of "regulatory T cells" that play a key role in immune function and suppression of autoimmune disease, according to new research in the Linus Pauling Institute at Oregon State University.This may be one of the underlying mechanisms for the health benefits of green tea, which has attracted wide interest for its ability to help control inflammation, improve immune function and prevent cancer.Oregon Sate Universityhttps://today.oregonstate.edu/archives/2011/jun/mechanism-discovered-health-benefit-green-tea-new-approach-autoimmune-disease
Over the counter and prescription medicines
Mucinex: (in its different forms of availability) was one of the most referred to in usage for over the counter medicine and seems to give really good results according to the feedback I got. It seems to help by simply thinning and loosening mucus in your airways and clearing congestion and in doing so, makes breathing easier. Use as needed, don’t use as a preventive medication. You should drink plenty of water when taking Mucinex.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5724298/
Pepsid (famotidine): A more recent mechanism that has been postulated is that famotidine's effect is achieved via its antagonism or inverse agonism of the histamine-2 receptor, inferring that the SARS-CoV-2 infection that results in COVID-19 is at least partially mediated by pathological histamine release and perhaps dysfunctional mast cell activation (5,8). Preventing the deleterious sequelae of this histamine release has been suggested as fundamental to preventing the cytokine storm that may cause acute respiratory distress syndrome, leading to hypoxia, sepsis, organ failure, and ultimately death in the patient with COVID-19 (8). Lower levels of ferritin, CRP, and procalcitonin in famotidine-treated patients in this study are compatible with the hypothesis that the drug may limit the abnormal excessive cytokine release from an uncontrolled immune activation. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7473796/
Colchicine: Anti-inflammatory- Colchicine is used to prevent gout attacks (sudden, severe pain in one or more joints caused by abnormally high levels of a substance called uric acid in the blood) in adults. Colchicine (Colcrys) is also used to relieve the pain of gout attacks when they occur. Over 2000 years usageSince it is used when gout attacks occur, it may have a fairly rapid affect.Seems to slow down the excessive immune response (cytokine storm) that happens with immune response to COVID-19 that leads to difficulty breathing.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7367785/ This is a link for continuing studies: https://clinicaltrials.gov/ct2/results?cond=COVID&term=colchicine&cntry=&state=&city=&dist=
Symbicort inhaler (Budesonide): are called preventers. They work by calming down your immune system. This reduces the swelling in your lungs that makes it difficult to breathe. It also helps prevent you getting symptoms such as wheezing and coughing. US Brand NamePulmicortPulmicort FlexhalerPulmicort RespulesPulmicort Turbuhaler Canadian Brand NamePulmicort NebuampRhinocort Turbuhaler Budesonide is used to help prevent the symptoms of asthma. When used regularly every day, inhaled budesonide decreases the number and severity of asthma attacks. However, it will not relieve an asthma attack that has already started.
Budesonide is a corticosteroid or steroid (cortisone-like medicine). It works by preventing inflammation (swelling) in the lungs, which makes the asthma attack less severe. Inhaled budesonide may be used with other asthma medicines such as bronchodilators, which are also used to open up narrowed breathing passages in the lungs.This medicine is available only with your doctor's prescription.It can treat Crohn's disease and ulcerative colitis in its oral form. When inhaled it can treat asthma. https://www.nhs.uk/medicines/budesonide-inhalers/#:~:text=Budesonide%20inhalers%20are%20called%20preventers,such%20as%20wheezing%20and%20coughing. Hydroxychloroquine (Plaquenil): is considered a disease-modifying anti-rheumatic drug (DMARD). It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Today, it is used to treat rheumatoid arthritis, some symptoms of lupus, childhood arthritis (or juvenile idiopathic arthritis) and other autoimmune diseases. It is not clear why hydroxychloroquine is effective at treating autoimmune diseases. It is believed that hydroxychloroquine interferes with the communication of cells in the immune system.American College of Rheumatologyhttps://www.rheumatology.org/I-Am-A/Patient-Caregiver/Treatments/Hydroxychloroquine-Plaquenil
Hydroxychloroquine is an antimalarial drug which is relatively safe and well-tolerated agent for the treatment of rheumatoid arthritis. Johns Hopkins Arthritis Centerhttps://www.hopkinsarthritis.org/arthritis-info/rheumatoid-arthritis/ra-treatment/#hydroxy
Hydroxychloroquine is a disease-modifying anti-rheumatic drug (DMARD). It regulates the activity of the immune system, which may be overactive in some conditions. Hydroxychloroquine can modify the underlying disease process, rather than simply treating the symptoms.https://www.versusarthritis.org/about-arthritis/treatments/drugs/hydroxychloroquine/
Ivermectin: Ivermectin is a drug of a wide range of bioactivity and has been in use for more than 30 years for treatment of parasitic infections in humans .It is being considered as the possible target drug for SARS CoV-2 and is under extensive research in clinical trials .Ivermectin is used in a dose of 0.15 mg/kg–0.2 mg/kg body weight for most of the parasitic infestations as oral tablet and is well tolerated. This is not the first time when the antiviral properties of ivermectin has been tested against human virus. Ivermectin has shown its potent in vitro antiviral effects against several RNA viruses, such as Zika virus, Influenza A virus, Newcastle disease virus, Chikungunya virus, Yellow fever virus, Dengue virus, Japanese encephalitis virus and DNA virus such as BK polyomavirus and Equine herpesvirus type 1 . The anti-SARS-CoV-2 affect of ivermectin is likely through inhibition of viral IMPα/β1-mediated nuclear import, which reduces the replication of virus and thereby the viral load .Caly et al. showed the in vitro benefit of ivermectin in Vero-hSLAM cells infected with SARS-CoV-2.The authors found that a single dose of ivermectin was able to effect ∼5000-fold reduction in viral RNA at 48 h .https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7521351/
Z-Pack (Azithromycin): (I personally wouldn't want to take this for a virus) the Z pack is a 5-day antibiotic treatment that does not work on the common cold. Viral infections cause the common cold, but the Z pack only works on bacterial infections. People should only use the Z pack under a doctor’s supervision, as taking antibiotics unnecessarily could do more harm than good.This could lead to potentially fatal complications in some cases.Some people are more at risk of experiencing difficulties from using this antibiotic, including those with:low blood levels of potassium or magnesiuma slower-than-normal heart ratearrhythmia, or an irregular heartbeatprolonged QT interval, or an irregularity that causes very fast and erratic heartbeatshttps://www.medicalnewstoday.com/articles/323770#is-the-z-pack-safe
Azithromycin is used to treat a wide variety of bacterial infections. It is a macrolide-type antibiotic. It works by stopping the growth of bacteria.This medication will not work for viral infections (such as common cold, flu). https://www.webmd.com/drugs/2/drug-20602/zithromax-z-pak-oral/details Based on the above I would personally not want to use Azithromycin in treatment of COVID-19. Antibiotics Hike Heart Risks
Dr. Chauncey Crandall, M.D., writes:
Azithromycin is one of the most commonly prescribed antibiotics on the market. Most people know it by the name Z-Pak.Millions of people have taken Z-Pak, which offers quick relief for patients dealing with bacterial infections such as bronchitis and pneumonia, as well as infections of the ears, lungs, and other organs. It also acts against malaria and sexually transmitted diseases.Z-Pak is so important that it’s on the World Health Organization’s list of essential drugs.But as beneficial as is this antibiotic, it can spell trouble for some. In 2013, the U.S. Food and Drug Administration (FDA) issued a warning that Z-Pak can increase the risk of a fatal irregular heartbeat in people with heart disease. This warning was only for people with heart problems, but I prefer that all my patients steer clear of this drug.
There are safer options, like amoxicillin.
Another type of antibiotic called macrolides (erythromycin, clarithromycin) can cause blood pressure to fall too low if people who are on high blood pressure medication use them.
A Canadian study looked at people age 66 and older who were taking a calcium channel blocker, which is often used to treat high blood pressure. The researchers identified 7,100 patients hospitalized for low blood pressure or shock while taking a calcium channel blocker.
Treatment with erythromycin increased the risk of low blood pressure almost six times, while clarithromycin increased the risk almost fourfold.
So, if you are taking a calcium channel blocker and you are prescribed an antibiotic, make sure to tell your doctor.
Dr. Chauncey W. Crandall is author of Dr. Crandall’s Heart Health Report newsletter. He is a Yale graduate and is chief of the Cardiac Transplant Program at the world-renowned Palm Beach Cardiovascular Clinic in Palm Beach Gardens, Florida. He practices interventional, vascular, and transplant cardiology.